Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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421
Tocris Bioscience™ BI 9321
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
422
Tocris Bioscience™ Abiraterone acetate
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Potent CYP17A1 inhibitor
423
Tocris Bioscience™ EM12-SO2F
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Potent covalent inhibitor of Cereblon
424
Tocris Bioscience™ Imipramine hydrochloride
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Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment
425
Tocris Bioscience™ NVS-CECR2-1, >98%
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CAS: 1992047-61-6 Molecular Formula: C27H37N5O2S
| CAS | 1992047-61-6 |
|---|---|
| Molecular Formula | C27H37N5O2S |
426
Tocris Bioscience™ Olanzapine
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CAS: 132539-06-1 Molecular Formula: C17H20N4S
| CAS | 132539-06-1 |
|---|---|
| Molecular Formula | C17H20N4S |
427
| CAS | 3734-33-6 |
|---|---|
| Synonym | unii-m5ba6gaf1o |
| Molecular Formula | C28H34N2O3 |
428
Tocris Bioscience™ ML 210
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Selectively kills mutant HRAS-expressing cells
429
Tocris Bioscience™ LW 6
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Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
| Target | Dehydrogenase Inhibitors |
|---|---|
| CAS | 934593-90-5 |
| Purity | 0.98 |
| Chemical Name or Material | Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C26H29NO5 |
430
Tocris Bioscience™ JW 74
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Wnt pathway inhibitor
| CAS | 863405-60-1 |
|---|---|
| Solubility | Soluble to 100mM in DMSO |
| Purity | >99% |
| Chemical Name or Material | 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C24H20N6O2S |
| Formula Weight | Observed MW: 456.52 |
431
Tocris Bioscience™ ONO 6818
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High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
432
Tocris Bioscience™ JH-II-127
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Potent and selective LRRK2 inhibitor
| CAS | 1700693-08-8 |
|---|---|
| Chemical Name or Material | [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H21ClN6O3 |
| Formula Weight | Observed MW: 416.87 |
| Assay Percent Range | >98% |
433
Tocris Bioscience™ TC-S 7009
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High affinity and selective HIF-2α inhibitor
| CAS | 1422955-31-4 |
|---|---|
| Chemical Name or Material | N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C12H6ClFN4O3 |
| Formula Weight | Observed MW: 308.65 |
| Assay Percent Range | >99% |
434
Tocris Bioscience™ 6-Bnz-cAMP sodium salt
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Cell permeable cAMP analog
435
Tocris Bioscience™ NVS PAK1 C
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Negative control of NVS PAK1 1
| Purity | 98% |
|---|---|
| Recommended Storage | Store at -20°C |
| Synonym | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide |
| Molecular Formula | C22H23ClF3N5O |
| Formula Weight | 465.91 |